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Hair Follicle Dermal Papilla Cells

Developmental origins of dermal papilla cells - The precursor of the hair follicle is a local thickening, also known as placode, of the embryonic epidermis, which is detectable at embryonic day 14.5 (E14.5) of mouse development. Soon after, a local condensation (dermal condensate) of fibroblasts forms beneath the placode. Reciprocal signalling between the condensate and the placode leads to proliferation of the overlying epithelium and downward extension of the new follicle into the dermis (Millar, 2002; Schneider et al., 2009; Ohyama et al., 2010; Yang and Cotsarelis, 2010). After the initial downward growth, the epithelial cells envelope the dermal condensate, thereby forming the mature DP. The DP then instructs the surrounding epithelial cells, now called matrix cells, to proliferate, move upward and differentiate into the multiple layers of the outgrowing hair shaft and the channel surrounding the hair shaft, called the inner root sheath (Millar, 2002; Schneider et al., 2009).

The role of the DP in the hair growth cycle - In postnatal life the hair follicles undergo cyclical growth. The resting phase is known as telogen, the growth phase as anagen and the regression phase as catagen (Müller-Röver et al., 2001; Schmidt-Ullrich and Paus, 2005; Ohyama et al., 2010; Yang and Cotsarelis, 2010). During catagen, the epithelial cells at the base of the follicle undergo apoptosis, but the DP remains intact and is pulled or migrates upwards, until it comes to rest next to the stem cells of the hair follicle bulge. This situation persists during telogen. In anagen, cells at the base of the follicle start to proliferate, which results in downward growth of the follicle and envelopment of the DP. DP cells themselves are thought to not divide. However, the number of cells in the DP increases during anagen, possibly as a result of replenishment from neighbouring cells of the dermal sheath (Tobin et al., 2003; Chi et al., 2010).

For the right patient, Having the right hair proportion and scalp characteristics, hair transplant surgery can be a life changing hair transplant cosmetic procedure. However, not every hair loss sufferer is a good candidate for surgical hair restoration or hair transplantation. Its important to fully understand the criteria that makes a good hair transplant candidate in order to make a better informed decision when considering surgical hair restoration. What a prospective hair transplant patient needs to remember is that there is a finite amount of donor hair that can be moved to the balding areas of the scalp, and If this hair isnt used in a prudent and efficient manner with hair transplant procedure, the outcome of the procedure will not meet a patients expectations. Do not underestimate the importance of discussing these issues with your hair transplant surgeon or hair transplant expert during your consultation. Providing the hair transplant surgeon/hair transplant expert with your honest expectations can better help him explain the reality of your particular situation why you need hair transplant, and discuss whether or not undergoing a hair transplant procedure is right for you. Its also important to note that the approach of surgically keeping up with your hair loss is not a practical way to address most patients situations. Unfortunately, this mentality has evolved through the flashy and high pressure, late night marketing that has been the cornerstone of the less than ethical side of the hair transplant industry. Having small procedures early on in the hair loss process can be disastrous. Many young men and women are mislead by this marketing approach and are forced to deal with the emotional and physical consequences of falling into this trap. Patients in the early ages of hair loss, who have a significant amount of hair run the risk of "shock loss" caused by the trauma of the surgical procedure. While in most cases, the native hair that was shocked out will return, it can take many months to appreciate the full result of the surgery, causing distress to those who are affected by this. In some cases the young patient might be left with less hair then before the procedure. Understanding who makes the right candidate for surgical hair restoration is vitally important during the decision making process. Consulting with a skilled and ethical hair transplant surgeon/ hair transplant expert will make this process easier. In general, the best candidates for hair transplant surgery are: Men who have been losing their hair due to genetic hair loss for more than four years, or who have progressed to a Norwood class III or above with hair loss. Men with realistic expectations who understand that their hair loss might continue to progress even if they are taking prescription medication to stop the progression. Men who have been balding for many years and whos pattern of loss has stabilized. Men and women who have lost hair due to trauma or burns. Men and women who have lost hair or who’s hairlines were raised due to other cosmetic procedures such as face-lifts and brow lifts. Women with stable donor hair who exhibit more of a male pattern, than a female diffuse unpatterned hair loss. Anagen and Hair Translant in Mumbai Video Gallery Always Authentic. We’re proud of our work and always feature real, natural photos & videos with no airbrushing. Hair transplants can have a remarkable impact on an individual’s appearance after successful procedure,be proud of the new way you feel of yourselves. We are proud to share before-and-after hair transplant videos of our real patients so you can see the kind of results you can expect from our unique hair transplant procedure with FUT and FUE hair transplant technique.