Call / WhatsApp   9222222407 / 9222222605

Enter Mobile to get Free Hairloss Prescription by Dr.Divya






Hair Restoration Scientic Papers

Blocking enzymes in hair follicles promotes hair growth

Inhibiting a family of enzymes inside hair follicles that are suspended in a resting state restores hair growth, a new study has found. In experiments with mouse and human hair follicles, researchers found that drugs that inhibit the Janus kinase (JAK) family of enzymes promote rapid and robust hair growth when directly applied to the skin. Within 3 weeks, mice that received topical ruxolitinib or tofacitinib had regrown nearly all their hair (right photo; drug was applied only to the right side of the mouse). Little to no hair growth occurred in control mice during the same timeframe (left photo).

Credit: From S. Harel et al., Sci. Adv. 1, e1500973 (2015). Distributed under a Creative Commons Attribution Non Commercial License 4.0 (CC BY-NC). 10.1126/sciadv.1500973

Inhibiting a family of enzymes inside hair follicles that are suspended in a resting state restores hair growth, a new study from researchers at Columbia University Medical Center has found. The research was published today in the online edition of Science Advances. In experiments with mouse and human hair follicles, Angela M. Christiano, PhD, and colleagues found that drugs that inhibit the Janus kinase (JAK) family of enzymes promote rapid and robust hair growth when directly applied to the skin. The study raises the possibility that drugs known as JAK inhibitors could be used to restore hair growth in multiple forms of hair loss such as that induced by male pattern baldness, and additional types that occur when hair follicles are trapped in a resting state. Two JAK inhibitors have been approved by the U.S. Food and Drug Administration. One is approved for treatment of blood diseases (ruxolitinib) and the other for rheumatoid arthritis (tofacitinib). Both are being tested in clinical trials for the treatment of plaque psoriasis and alopecia areata, an autoimmune disease that causes hair loss. What we've found is promising, though we haven't yet shown it is effective for male pattern baldness," said Dr. Christiano. "More work needs to be done to test formulations of JAK inhibitors specially made for the scalp to determine whether they can induce hair growth in humans. Christiano and her colleagues serendipitously discovered the effect of JAK inhibitors on hair follicles when they were studying a type of hair loss known as alopecia areata, caused by an autoimmune attack on the hair follicles. Christiano and colleagues reported last year that JAK inhibitors shut off the signal that provokes the autoimmune attack, and that oral forms of the drug restore hair growth in some people with the disorder. In the course those experiments, Dr. Christiano noticed that mice grew more hair when the drug was applied topically to the skin than when given internally. This suggested JAK inhibitors might have a direct effect on the hair follicles in addition to inhibiting the immune attack. When the researchers looked more closely at normal mouse hair follicles, they found that JAK inhibitors rapidly awakened resting follicles out of dormancy. Hair follicles do not produce hair constantly but rather by cycling between resting and growing phases. JAK inhibitors trigger the follicles normal reawakening process, the researchers found. Mice treated for five days with one of two JAK inhibitors sprouted new hair within 10 days, greatly accelerating the hair follicle growth phase. No hair grew on untreated control mice in the same time period. There are very few compounds that can push hair follicles into their growth cycle so quickly, said Dr. Christiano. Some topical agents induce tufts of hair here and there after a few weeks, but very few have such a potent and rapid-acting effect.The drugs also produce longer hair from human hair follicles grown in culture and on skin grafted onto mice. Its likely that the drugs that are so effective in enhancing hair growth in the mice could affect the same pathways in human follicles, suggesting they could induce new hair growth and extend the growth of existing hairs in humans. It remains to be seen if JAK inhibitors can reawaken hair follicles that have been suspended in a resting state because of androgenetic alopecia (which causes male and female pattern baldness) or other forms of hair loss. So far, all the experiments have been conducted in normal mice and human follicles. Experiments to address hair follicles affected by hair loss disorders are under way. The title of the paper is: Pharmacologic inhibition of JAK-STAT signaling promotes hair growth. Other CUMC authors: Sivan Harel, Claire Higgins (now at Imperial College London) Jane E. Cerise, Zhenpeng Dai, James C. Chen, and Raphael Clynes (now at Bristol-Myers Squib). The work was supported in part by the NIH (grants R01AR056016, P30AR044535, T32GM082771 and T32GM007088), Locks of Love Foundation, Alopecia Areata Initiative, and the Dermatology Foundation (Career Development Award).

Story Source:
The above post is reprinted from materials provided by
Columbia University Medical Center.
Note: Materials may be edited for content and length.
Date:October 23, 2015

For the right patient, Having the right hair proportion and scalp characteristics, hair transplant surgery can be a life changing hair transplant cosmetic procedure. However, not every hair loss sufferer is a good candidate for surgical hair restoration or hair transplantation. Its important to fully understand the criteria that makes a good hair transplant candidate in order to make a better informed decision when considering surgical hair restoration. What a prospective hair transplant patient needs to remember is that there is a finite amount of donor hair that can be moved to the balding areas of the scalp, and If this hair isnt used in a prudent and efficient manner with hair transplant procedure, the outcome of the procedure will not meet a patients expectations. Do not underestimate the importance of discussing these issues with your hair transplant surgeon or hair transplant expert during your consultation. Providing the hair transplant surgeon/hair transplant expert with your honest expectations can better help him explain the reality of your particular situation why you need hair transplant, and discuss whether or not undergoing a hair transplant procedure is right for you. Its also important to note that the approach of surgically keeping up with your hair loss is not a practical way to address most patients situations. Unfortunately, this mentality has evolved through the flashy and high pressure, late night marketing that has been the cornerstone of the less than ethical side of the hair transplant industry. Having small procedures early on in the hair loss process can be disastrous. Many young men and women are mislead by this marketing approach and are forced to deal with the emotional and physical consequences of falling into this trap. Patients in the early ages of hair loss, who have a significant amount of hair run the risk of "shock loss" caused by the trauma of the surgical procedure. While in most cases, the native hair that was shocked out will return, it can take many months to appreciate the full result of the surgery, causing distress to those who are affected by this. In some cases the young patient might be left with less hair then before the procedure. Understanding who makes the right candidate for surgical hair restoration is vitally important during the decision making process. Consulting with a skilled and ethical hair transplant surgeon/ hair transplant expert will make this process easier. In general, the best candidates for hair transplant surgery are: Men who have been losing their hair due to genetic hair loss for more than four years, or who have progressed to a Norwood class III or above with hair loss. Men with realistic expectations who understand that their hair loss might continue to progress even if they are taking prescription medication to stop the progression. Men who have been balding for many years and whos pattern of loss has stabilized. Men and women who have lost hair due to trauma or burns. Men and women who have lost hair or who’s hairlines were raised due to other cosmetic procedures such as face-lifts and brow lifts. Women with stable donor hair who exhibit more of a male pattern, than a female diffuse unpatterned hair loss. Anagen and Hair Translant in Mumbai Video Gallery Always Authentic. We’re proud of our work and always feature real, natural photos & videos with no airbrushing. Hair transplants can have a remarkable impact on an individual’s appearance after successful procedure,be proud of the new way you feel of yourselves. We are proud to share before-and-after hair transplant videos of our real patients so you can see the kind of results you can expect from our unique hair transplant procedure with FUT and FUE hair transplant technique.